学位英语

Pregnant women warned about ACE1 inhibitor

Some of the most commonly used medicines for high blood pressure are drugs called ACE inhibitors. Doctors have given these drugs to patients for twenty-five years. A government study in the United States found that the use almost doubled between 1995 and 2000.

Doctors have known for years that women should not take ACE inhibitors during the last six months of pregnancy. The medicine can injure the baby. ACE inhibitors, though, have been considered safe when taken during the first three months. But a new study has found that women who take these drugs early in their pregnancy still increase the risk of birth disorders.2 The study shows that, compared to others, their babies were almost three times as likely to be born with major problems.3 These included problems with the formation of the brain and nervous system and holes in the heart.

The researchers say they found no increased risk in women who took other blood pressure medicines during the first three months. Researchers at Vanderbilt University in Tennessee and Boston University did the study. The New England Journal of Medicine4 published the results. The researchers studied the records of almost thirty thousand births between 1985 and 2000. Two hundred nine babies were born to women who took ACE inhibitors during the first three months of their pregnancies. Eighteen of the babies, or almost nine percent, had major disorders.

ACE inhibitors are often given to patients with diabetes. But diabetes during pregnancy can result in birth defects.5 So the study did not include any women known to be diabetic. ACE inhibitors suppress a protein called angiotensin-converting enzyme, or ACE. This enzyme produces a chemical in the body that makes blood passages narrow. The drugs increase the flow of blood so pressure is reduced.

New drugs are tested on pregnant animals to see if they might cause birth defects in humans. But experts say these tests are not always dependable. The United States Food and Drug Administration6 helped pay for the study. The F.D.A. says women who might become pregnant should talk with their doctor about other ways to treat high blood pressure.

词汇：

pregnant adj. 怀孕的

inhibitor n. 抑制剂

pregnancy n. 怀孕

diabetes n. 糖尿病

diabetic adj. 糖尿病的 n. 糖尿病患者

suppress vt. 抑制

dependable adj. 可靠的

注释：

1.ACE (angiotensin-converting enzyme)：血管紧张肽转化酶

2.birth disorders：先天性疾病

3. The study shows that, compared to others, their babies were almost three times as likely to be born with major problems. 这项研究表明，如果与其他婴儿相比，这些婴儿在出生时患大病的可能性几乎是他们的三倍。compare to在美国英语中也有 compared with(与...相比)的意思。另外，problem在医学文献中常常用来指疾病。

4. New England Journal of Medicine：新英格兰医药杂志。New England 是美国东北六州 ( Maine, Vermont, New Hampshire, Massachusetts, Rhode Island 和 Connecticut )的总称。

5 birth defect ( = congenital defect)：先天性缺陷，先天性缺损

6. United States Food and Drug Administration (FDA)：美国食品与药品管理局

练习：

1. Paragraph 2

2. Paragraph 3

3. Paragraph 4

4. Paragraph 5

A Effects of ACE and ACE inhibitors

B Wide use of ACE inhibitors

C How to deal with high blood pressure in pregnant women

D Damage to pregnant women's future babies

E Suggestions on stopping the use of ACE inhibitors

F Relative safety for women during the first three months of pregnancies

5. FDA suggests that pregnant women with high blood pressure should consult

6. ACE inhibitors are not recommended

7. Evidence showed only a small percentage of babies suffered major disorders

8. ACE is a risk factor to our body

A that may cause our blood vessels to become more and more narrow

B for pregnant women to take during their last six months of pregnancies

C that their likelihood to suffer major problems is two times higher than other babies

D with their doctors about how to treat their problems

E because diabetes during pregnancy may sometimes lead to birth defects

F though their mothers took ACE inhibitors during their first three months of pregnancies

1.分析文章标题： Pregnant(怀孕的) women warned about/of (被警告...)ACE (血管紧张肽转化酶)inhibitor(抑制剂)

文章主题词：pregnant women, warn, ACE inhibitor

2. 分析小标题被选项：

A Effects (影响)of ACE and ACE inhibitors(抑制剂)

B Wide(广泛的) use (使用)of ACE inhibitors

C How to deal with (处理，应对)high blood pressure (高血压)in pregnant women

D Damage to(对...的损害) pregnant women's future(未来的) babies(婴儿)

E Suggestions on (关于...的建议)stopping(停止) the use of ACE inhibitors

F Relative(相对的， 有关系的) safety(安全) for women during(在...期间) the first three months of pregnancies (怀孕)

所有的被选项都直接或间接地涉及到了文章主题词， 因此这些选项成为答案的可能性均较大。

1.解答概括大意题：

A Effects (影响)of ACE and ACE inhibitors(抑制剂)

B Wide(广泛的) use (使用)of ACE inhibitors

C How to deal with (应对)high blood pressure (高血压)in pregnant women

D Damage to(对...的损害) pregnant women's future(未来的) babies(婴儿)

E Suggestions on (关于...的建议)stopping(停止) the use of ACE inhibitors

F Relative(相对的) safety(安全) for women during(在...期间) the first three months of pregnancies (怀孕)

1.Paragraph 2

Doctors have known (已经知道)for years that women should not take(服用) ACE inhibitors during(在...期间) the last (最后的， 最近的)six months of pregnancy. The medicine(药品) can injure(伤害) the baby. ACE inhibitors, though, have been considered safe when taken during the first three months. But a new study has found that women who take these drugs early in their pregnancy still increase the risk of birth disorders.2 The study shows that, compared to others, their babies were almost three times as likely to be born with major problems.3 These included problems with the formation of the brain and nervous system and holes in the heart.

1.D baby连同它的词义相关词共出现了4次， 而且是贯穿全段出现，因此baby是段落主题词，由此判断D可能是答案。 段落开头的语句与D内容一致，因此进一步确认D是答案。 第二段说的是孕妇在孕期最后六个月服用ACE抑制剂会给未来婴儿带来伤害，婴儿患大病的可能性几乎是其他婴儿的三倍，包括大脑和神经系统发育缺陷及心脏出现空洞等。

A Effects (影响)of ACE and ACE inhibitors(抑制剂)

B Wide(广泛的) use (使用)of ACE inhibitors

C How to deal with (应对)high blood pressure (高血压)in pregnant women

E Suggestions on (关于...的建议)stopping(停止) the use of ACE inhibitors

F Relative(相对的， 有关系的) safety(安全) for women during(在...期间) the first three months of pregnancies (怀孕)

2.Paragraph 3

The researchers say (说)they found(发现) no increased(增加的) risk(风险) in women who took(服用) other blood pressure(血压) medicines(药) during the first three months. Researchers at Vanderbilt University in Tennessee and Boston University did the study. The New England Journal of Medicine4 published the results. The researchers studied the records of almost thirty thousand births between 1985 and 2000. Two hundred nine babies were born to (由...生出)women who took(服用) ACE inhibitors during the first three months of their pregnancies(怀孕). Eighteen of the babies, or(即) almost nine percent, had major (主要的，严重的)disorders(紊乱).

1.F 段落段首句及段尾部分的句子均表明：服用的ACE的孕妇生下的孩子大部分没有什么严重的影响， 因此F是答案。第三段说患高血压的孕妇在孕期头三个月服用其它降压药，她们的危险性并没有增加;即使服用ACE抑制剂，其婴儿也只有大约9%患大病。故妊娠头三个月相对安全。

A Effects (影响)of ACE and ACE inhibitors(抑制剂)

B Wide(广泛的) use (使用)of ACE inhibitors

C How to deal with (处理，应对)high blood pressure (高血压)in pregnant women

E Suggestions on (关于...的建议)stopping(停止) the use of ACE inhibitors

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